Association between a history of TBI and cognitive decline in subjects with
autopsy confirmed AD
 
   Lead Investigator:    Michael Alosco
   Institution      :    Boston ADC
   E-Mail           :    malosco@bu.edu
   Proposal ID      :    993


   Publications:


1  Sugarman MA, McKee AC, Stein TD, Tripodis Y,   Besser LM , Martin B, Palmisano JN, Steinberg EG, O'Connor MK, Au R, McClean M, Killiany R, Mez J, Weiner MW, Kowall NW, Stern RA, Alosco ML
   Failure to detect an association between self-reported traumatic brain injury and Alzheimer's disease neuropathology and dementia
   Journal Article  Alzheimers Dement,5:686-698,2019,PMC6511462

   PUBLISHED





   Proposal Description:
   The primary objective of the paper is to look at the association between a history of TBI (with brief and extended LOC) and cognitive decline in subjects with autopsy confirmed AD. This will extend our recent NACC paper by Tripodis et al looking at this in living AD subjects. The paper would also look at the association between TBI and ADNP.  The sample would be all autopsy subjects with neuropath data and then a separate variable that codes those with and without ADNP. Goal is to examine how TBI affects cognitive change in AD by using subjects with known pathology.